The effect of physical activity on white matter integrity in aging and prodromal to mild Alzheimer's disease with vascular comorbidity.

ABSTRACT:

Background

Physical activity is a modifiable lifestyle factor that has been previously associated with reduced vascular burden and reduced risk of dementia.

Objectives

This study tested whether physical activity (i.e., being inactive vs. active) contributed to preservation of white matter microstructure in healthy aging controls and patients in prodromal to mild Alzheimer's disease with low/high vascular burden.

Materials

A total of 213 participants were recruited from memory clinics. They were classified as being either physically active (n = 113) or inactive (n = 100) based on the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) questionnaire. Diffusion-weighted images were acquired for all participants and pre-processed based on a standard prot

SUBMITTER: Konwar S 

PROVIDER: S-EPMC10382177 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature