Association of BMAL1 clock gene polymorphisms with fasting glucose in children.

ABSTRACT:

Background

The brain and muscle Arnt-like protein-1 (BMAL1) gene is an important circadian clock gene and previous studies have found that certain polymorphisms are associated with type 2 diabetes in adults. However, it remains unknown if such polymorphisms can affect fasting glucose in children and if other factors modify the associations.

Methods

A school-based cross-sectional study with 947 Chinese children was conducted. A multivariable linear regression model was used to analyze the association between BMAL1 gene polymorphisms and fasting glucose level.

Results

After adjusting for age, sex, body mass index (BMI), physical activity, and unhealthy diet, GG genotype carriers of BMAL1 rs3789327 had higher fasting glucose than AA/GA genotype carriers (b = 0.101, SE = 

SUBMITTER: Yang YD 

PROVIDER: S-EPMC10382306 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature