Urinary epidermal growth factor predicts complete remission of proteinuria in Chinese children with IgA nephropathy.

ABSTRACT:

Background

This study investigated the association between urinary epidermal growth factor (EGF) and complete remission (CR) of proteinuria in children with IgA nephropathy (IgAN).

Methods

We included 108 patients from the Registry of IgA Nephropathy in Chinese Children. The urinary EGF at the baseline and follow-up were measured and normalized by urine creatinine (expressed as uEGF/Cr). The person-specific uEGF/Cr slopes were estimated using linear mixed-effects models for the subset of patients with longitudinal data of uEGF/Cr. Cox models were used to analyze the associations of baseline uEGF/Cr and uEGF/Cr slope with CR of proteinuria.

Results

Patients with high baseline uEGF/Cr were more likely to achieve CR of proteinuria (adjusted HR 2.24, 95% CI: 1.05-4.79). T

SUBMITTER: Zhou J 

PROVIDER: S-EPMC10382307 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature