Dataset Information

Linking specific biological signatures to different childhood adversities: findings from the HERO project.

ABSTRACT:

Background

Although investigations have begun to differentiate biological and neurobiological responses to a variety of adversities, studies considering both endocrine and immune function in the same datasets are limited.

Methods

Associations between proximal (family functioning, caregiver depression, and anxiety) and distal (SES-D; socioeconomic disadvantage) early-life adversities with salivary inflammatory biomarkers (IL-1β, IL-6, IL-8, and TNF-α) and hair HPA markers (cortisol, cortisone, and dehydroepiandrosterone) were examined in two samples of young U.S. children (N = 142; N = 145).

Results

Children exposed to higher SES-D had higher levels of TNF-α (B = 0.13, p = 0.011), IL-1β (B = 0.10, p = 0.033), and DHEA (B = 0.16, p = 0.011). Higher family dysfunction was associated with higher cortisol (B = 0.08, p = 0.033) and cortisone (B = 0.05, p = 0.003). An interaction between SES-D and family dysfunction was observed for cortisol levels (p = 0.020) whereby children exposed to lower/average levels of SES-D exhibited a positive association between family dysfunction and cortisol levels, whereas children exposed to high levels of SES-D did not. These findings were partially replicated in the second sample.

Conclusions

Our results indicate that these biological response systems may react differently to different forms of early-life adversity.

Impact

Different forms of early-life adversity have varied stress signatures, and investigations of early-life adversities with inflammation and HPA markers are lacking. Children with higher socioeconomic disadvantage had higher TNF-α, IL-1β, and DHEA. Higher family dysfunction was associated with higher hair cortisol and cortisone levels, and the association between family dysfunction and cortisol was moderated by socioeconomic disadvantage. Biological response systems (immune and endocrine) were differentially associated with distinct forms of early-life adversities.

SUBMITTER: de Mendonca Filho EJ

PROVIDER: S-EPMC10382309 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Publications

Linking specific biological signatures to different childhood adversities: findings from the HERO project.

de Mendonça Filho Euclides José EJ Pokhvisneva Irina I Maalouf Christina Maria CM Parent Carine C Mliner Shanna B SB Slopen Natalie N Williams David R DR Bush Nicole R NR Boyce William Thomas WT Levitt Pat P Nelson Charles A CA Gunnar Megan R MR Meaney Michael J MJ Shonkoff Jack P JP Silveira Patricia Pelufo PP

Pediatric research 20230117 2

<h4>Background</h4>Although investigations have begun to differentiate biological and neurobiological responses to a variety of adversities, studies considering both endocrine and immune function in the same datasets are limited.<h4>Methods</h4>Associations between proximal (family functioning, caregiver depression, and anxiety) and distal (SES-D; socioeconomic disadvantage) early-life adversities with salivary inflammatory biomarkers (IL-1β, IL-6, IL-8, and TNF-α) and hair HPA markers (cortisol ...[more]

PMID: 36650307

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Dataset Information

Linking specific biological signatures to different childhood adversities: findings from the HERO project.

Background

Methods

Results

Conclusions

Impact

Publications

Linking specific biological signatures to different childhood adversities: findings from the HERO project.

Similar Datasets

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