Vaccine evaluation and genotype characterization in children infected with rotavirus in Qatar.

ABSTRACT:

Background

We characterized and identified the genetic and antigenic variations of circulating rotavirus strains in comparison to used rotavirus vaccines.

Methods

Rotavirus-positive samples (n = 231) were collected and analyzed. The VP7 and VP4 genes were sequenced and analyzed against the rotavirus vaccine strains. Antigenic variations were illustrated on the three-dimensional models of surface proteins.

Results

In all, 59.7% of the hospitalized children were vaccinated, of which only 57.2% received two doses. There were no significant differences between the vaccinated and non-vaccinated groups in terms of clinical outcome. The G3 was the dominant genotype (40%) regardless of vaccination status. Several amino acid changes were identified in the VP7 and VP4 antigenic

SUBMITTER: Mathew S 

PROVIDER: S-EPMC10382313 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature