Neoantigen-specific stem cell memory-like CD4⁺ T cells mediate CD8⁺ T cell-dependent immunotherapy of MHC class II-negative solid tumors.

ABSTRACT: CD4⁺ T cells play key roles in a range of immune responses, either as direct effectors or through accessory cells, including CD8⁺ T lymphocytes. In cancer, neoantigen (NeoAg)-specific CD8⁺ T cells capable of direct tumor recognition have been extensively studied, whereas the role of NeoAg-specific CD4⁺ T cells is less well understood. We have characterized the murine CD4⁺ T cell response against a validated NeoAg (CLTC_H129>Q) expressed by the MHC-II-deficient squamous cell carcinoma tumor model (SCC VII) at the level of single T cell receptor (TCR) clonotypes and in the setting of adoptive immunotherapy. We find that the natural CLTC_H129>Q-specific repertoire is diverse and contains TCRs with distinct avidities as

SUBMITTER: Brightman SE 

PROVIDER: S-EPMC10382322 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature