In-line warming reduces in-line pressure of subcutaneous infusion of concentrated immunoglobulins.

ABSTRACT: Immunoglobulin replacement therapy is a life-saving treatment in patients with immunodeficiency and effective in the management of autoimmune disorders. Immunoglobulins are administered intravenously or subcutaneously, with the latter route reducing systemic reactions and providing an option for self-infusion, increasing patient convenience, while decreasing patient burden, healthcare utilization, and costs. A major limitation with subcutaneous administrations is the frequency of infusion due to limited volumes administrable into subcutaneous space, necessitating increased drug concentration, absorption, and dispersion. Increasing the concentration of immunoglobulins from 10 to 20% halves the required volume, but leads to higher dynamic viscosity, limiting infusion rate. Recombinant human

SUBMITTER: Leidenmuhler P 

PROVIDER: S-EPMC10382333 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature