Development and external validation of a multivariable [⁶⁸Ga]Ga-PSMA-11 PET-based prediction model for lymph node involvement in men with intermediate or high-risk prostate cancer.

ABSTRACT:

Purpose

To develop and evaluate a lymph node invasion (LNI) prediction model for men staged with [⁶⁸Ga]Ga-PSMA-11 PET.

Methods

A consecutive sample of intermediate to high-risk prostate cancer (PCa) patients undergoing [⁶⁸Ga]Ga-PSMA-11 PET, extended pelvic lymph node dissection (ePLND), and radical prostatectomy (RP) at two tertiary referral centers were retrospectively identified. The training cohort comprised 173 patients (treated between 2013 and 2017), the validation cohort 90 patients (treated between 2016 and 2019). Three models for LNI prediction were developed and evaluated using cross-validation. Optimal risk-threshold was determined during model development. The best performing model was evaluated and compared to available conventional and mul

SUBMITTER: Muehlematter UJ 

PROVIDER: S-EPMC10382335 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature