Submandibular gland involvement in oral cavity squamous cell carcinoma: a retrospective multicenter study.

ABSTRACT:

Background

The submandibular gland (SMG) is routinely excised during neck dissection. Given the importance of the SMG in saliva production, it is important to understand its involvement rate by cancer tissue and the feasibility of its preservation.

Methods

Retrospective data were collected from five academic centers in Europe. The study involved adult patients affected by primary oral cavity carcinoma (OCC) undergoing tumor excision and neck dissection. The main outcome analyzed was the SMG involvement rate. A systematic review and a meta-analysis were also conducted to provide an updated synthesis of the topic.

Results

A total of 642 patients were enrolled. The SMG involvement rate was 12/642 (1.9%; 95% CI 1.0-3.2) when considered per patient, and 12/852 (1.4%; 95% C

SUBMITTER: Iocca O 

PROVIDER: S-EPMC10382344 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature