Genomic distribution and polymorphism of G-quadruplex motifs occupying ovine promoters and enhancers.

ABSTRACT: G-quadruplexes are non-canonical DNA structures that are formed in regions with short runs of guanines. During the last decade they have gained considerable attention due to their involvement in basic cellular processes, linking them to several physiological processes and pathological conditions. Regulation of gene transcription is among the crucial roles that G-quadruplexes play in the cells. Several ways in which these structures affect transcription have been described, both negatively and positively. Recently, G-quadruplexes have been shown to be implicated in the three-dimensional rearrangement of the chromosomes that enables the interaction of enhancers and gene promoters during regulation of transcription. Sheep is a species for which almost no G-quadruplex-related studies have been

SUBMITTER: Stefos GC 

PROVIDER: S-EPMC10382345 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature