In vivo evaluation of a novel ¹⁸F-labeled PET radioligand for translocator protein 18 kDa (TSPO) in monkey brain.

ABSTRACT:

Purpose

[¹⁸F]SF51 was previously found to have high binding affinity and selectivity for 18 kDa translocator protein (TSPO) in mouse brain. This study sought to assess the ability of [¹⁸F]SF51 to quantify TSPO in rhesus monkey brain.

Methods

Positron emission tomography (PET) imaging was performed in monkey brain (n = 3) at baseline and after pre-blockade with the TSPO ligands PK11195 and PBR28. TSPO binding was calculated as total distribution volume corrected for free parent fraction in plasma (V_T/f_P) using a two-tissue compartment model. Receptor occupancy and nondisplaceable uptake were determined via Lassen plot. Binding potential (BP_ND) was calculated as the ratio of specific binding to nondisplaceable uptake. Time

SUBMITTER: Yan X 

PROVIDER: S-EPMC10382351 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature