Spatial and temporal diversity of positive selection on shared haplotypes at the PSCA locus among worldwide human populations.

ABSTRACT: Selection on standing genetic variation is important for rapid local genetic adaptation when the environment changes. We report that, for the prostate stem cell antigen (PSCA) gene, different populations have different target haplotypes, even though haplotypes are shared among populations. The C-C-A haplotype, whereby the first C is located at rs2294008 of PSCA and is a low risk allele for gastric cancer, has become a target of positive selection in Asia. Conversely, the C-A-G haplotype carrying the same C allele has become a selection target mainly in Africa. However, Asian and African share both haplotypes, consistent with the haplotype divergence time (170 kya) prior to the out-of-Africa dispersal. The frequency of C-C-A/C-A-G is 0.344/0.278 in Asia and 0.209/0.416 in Africa. Two-dimens

SUBMITTER: Iwasaki RL 

PROVIDER: S-EPMC10382566 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature