In vitro and in vivo antiplasmodial evaluation of sugar-modified nucleoside analogues.

ABSTRACT: Drug-resistant Plasmodium falciparum (Pf) infections are a major burden on the population and the healthcare system. The establishment of Pf resistance to most existing antimalarial therapies has complicated the problem, and the emergence of resistance to artemisinin derivatives is even more concerning. It is increasingly difficult to cure malaria patients due to the limited availability of effective antimalarial drugs, resulting in an urgent need for more efficacious and affordable treatments to eradicate this disease. Herein, new nucleoside analogues including morpholino-nucleoside hybrids and thio-substituted nucleoside derivatives were prepared and evaluated for in vitro and in vivo antiparasitic activity that led a few hits especially nucleoside-thiopyranoside conjugates, which are hi

SUBMITTER: Bege M 

PROVIDER: S-EPMC10382589 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature