Higher levels of serum α-Klotho are longitudinally associated with less central obesity in girls experiencing weight gain.

ABSTRACT:

Introduction

Klotho is an anti-aging protein that reduces adiposity and increases caloric expenditure, among others. Although associations between secreted α-Klotho levels and obesity have been described, its relationship with central obesity and visceral fat accumulation during childhood is poorly understood. Our objective was to study the longitudinal associations between serum α-Klotho concentrations and obesity-related parameters in apparently healthy children.

Subjects and methods

We studied a cohort of 208 apparently healthy school-age children (107 girls and 101 boys) assessed at baseline (mean age 8.5 ± 1.8 years) and at follow-up 4 years later. Serum α-Klotho concentrations were measured at baseline in all subjects. Obesity-related parameters, such as BMI, waist cir

SUBMITTER: Carreras-Badosa G 

PROVIDER: S-EPMC10382686 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature