Anxiety Shapes Amygdala-Prefrontal Dynamics During Movie Watching.

ABSTRACT:

Background

A well-characterized amygdala-dorsomedial prefrontal circuit is thought to be crucial for threat vigilance during anxiety. However, engagement of this circuitry within relatively naturalistic paradigms remains unresolved.

Methods

Using an open functional magnetic resonance imaging dataset (Cambridge Centre for Ageing Neuroscience; n = 630), we sought to investigate whether anxiety correlates with dynamic connectivity between the amygdala and dorsomedial prefrontal cortex during movie watching.

Results

Using an intersubject representational similarity approach, we saw no effect of anxiety when comparing pairwise similarities of dynamic connectivity across the entire movie. However, preregistered analyses demonstrated a relationship between anxiety, am

SUBMITTER: Kirk PA 

PROVIDER: S-EPMC10382705 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature