Proteomic Analysis Identifies Circulating Proteins Associated With Plasma Amyloid-β and Incident Dementia.

ABSTRACT:

Background

Plasma amyloid-β (Aβ) (Aβ₄₂, Aβ₄₀, and Aβ₄₂/Aβ₄₀), biomarkers of the Alzheimer's form of dementia, are under consideration for clinical use. The associations of these peptides with circulating proteins may identify novel plasma biomarkers of dementia and inform peripheral factors influencing the levels of these peptides.

Methods

We analyzed the association of these 3 plasma Aβ measures with 4638 circulating proteins among a subset of the participants of the Atherosclerosis Risk in Communities (ARIC) study (midlife: n = 1955; late life: n = 2082), related the Aβ-associated proteins with incident dementia in the overall ARIC cohort (midlife: n = 11,069, late life: n = 4110) with external replica

SUBMITTER: Tin A 

PROVIDER: S-EPMC10382706 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature