Mechanical transmission of dengue virus by Aedes aegypti may influence disease transmission dynamics during outbreaks.

ABSTRACT:

Background

Dengue virus outbreaks are increasing in number and severity worldwide. Viral transmission is assumed to require a minimum time period of viral replication within the mosquito midgut. It is unknown if alternative transmission periods not requiring replication are possible.

Methods

We used a mouse model of dengue virus transmission to investigate the potential of mechanical transmission of dengue virus. We investigated minimal viral titres necessary for development of symptoms in bitten mice and used resulting parameters to inform a new model of dengue virus transmission within a susceptible population.

Findings

Naïve mice bitten by mosquitoes immediately after they took partial blood meals from dengue infected mice showed symptoms of dengue virus, followed

SUBMITTER: Li HH 

PROVIDER: S-EPMC10382859 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature