Saliva microbiome in relation to SARS-CoV-2 infection in a prospective cohort of healthy US adults.

ABSTRACT:

Background

The clinical outcomes of SARS-CoV-2 infection vary in severity, potentially influenced by the resident human microbiota. There is limited consensus on conserved microbiome changes in response to SARS-CoV-2 infection, with many studies focusing on severely ill individuals. This study aimed to assess the variation in the upper respiratory tract microbiome using saliva specimens in a cohort of individuals with primarily mild to moderate disease.

Methods

In early 2020, a cohort of 831 adults without known SARS-CoV-2 infection was followed over a six-month period to assess the occurrence and natural history of SARS-CoV-2 infection. From this cohort, 81 participants with a SARS-CoV-2 infection, along with 57 unexposed counterparts were selected with a total of 748 seria

SUBMITTER: Armstrong AJS 

PROVIDER: S-EPMC10382861 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature