Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration.

ABSTRACT:

Background & aims

Liver regeneration is a repair process in which metabolic reprogramming of parenchymal and inflammatory cells plays a major role. Monoacylglycerol lipase (MAGL) is an ubiquitous enzyme at the crossroad between lipid metabolism and inflammation. It converts monoacylglycerols into free fatty acids and metabolises 2-arachidonoylglycerol into arachidonic acid, being thus the major source of pro-inflammatory prostaglandins in the liver. In this study, we investigated the role of MAGL in liver regeneration.

Methods

Hepatocyte proliferation was studied in vitro in hepatoma cell lines and ex vivo in precision-cut human liver slices. Liver regeneration was investigated in mice treated with a pharmacological MAGL inhibitor, MJN110, as well as in animals

SUBMITTER: Allaire M 

PROVIDER: S-EPMC10382928 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature