Race, Ethnicity, and Pharmacogenomic Variation in the United States and the United Kingdom.

ABSTRACT: The relevance of race and ethnicity to genetics and medicine has long been a matter of debate. An emerging consensus holds that race and ethnicity are social constructs and thus poor proxies for genetic diversity. The goal of this study was to evaluate the relationship between race, ethnicity, and clinically relevant pharmacogenomic variation in cosmopolitan populations. We studied racially and ethnically diverse cohorts of 65,120 participants from the United States All of Us Research Program (All of Us) and 31,396 participants from the United Kingdom Biobank (UKB). Genome-wide patterns of pharmacogenomic variation-6311 drug response-associated variants for All of Us and 5966 variants for UKB-were analyzed with machine learning classifiers to predict participant

SUBMITTER: Sharma S 

PROVIDER: S-EPMC10383154 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature