Administration of mRNA-Nanomedicine-Augmented Calvarial Defect Healing via Endochondral Ossification.

ABSTRACT: Large-area craniofacial defects remain a challenge for orthopaedists, hastening the need to develop a facile and safe tissue engineering strategy; osteoconductive material and a combination of optimal growth factors and microenvironment should be considered. Faced with the unmet need, we propose that abundant cytokines and chemokines can be secreted from the bone defect, provoking the infiltration of endogenous stem cells to assist bone regeneration. We can provide a potent mRNA medicine cocktail to promptly initiate the formation of bone templates, osteogenesis, and subsequent bone matrix deposition via endochondral ossification, which may retard rapid fibroblast infiltration and prevent the formation of atrophic non-union. We explored the mutual interaction of BMP2 and TGFβ3 mRNA, both p

SUBMITTER: Tsou HK 

PROVIDER: S-EPMC10383176 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature