A Tale about Shigella: Evolution, Plasmid, and Virulence.

ABSTRACT: Shigella spp. cause hundreds of millions of intestinal infections each year. They target the mucosa of the human colon and are an important model of intracellular bacterial pathogenesis. Shigella is a pathovar of Escherichia coli that is characterized by the presence of a large invasion plasmid, pINV, which encodes the characteristic type III secretion system and icsA used for cytosol invasion and cell-to-cell spread, respectively. First, we review recent advances in the genetic aspects of Shigella, shedding light on its evolutionary history within the E. coli lineage and its relationship to the acquisition of pINV. We then discuss recent insights into the processes that allow for the maintenance of pINV. Finally, we describe the role of the transc

SUBMITTER: Haidar-Ahmad N 

PROVIDER: S-EPMC10383432 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature