Development and Optimal Immune Strategy of an Alum-Stabilized Pickering emulsion for Cancer Vaccines.

ABSTRACT: Therapeutic cancer vaccines are considered as one of the most cost-effective ways to eliminate cancer cells. Although many efforts have been invested into improving their therapeutic effect, transient maturation and activations of dendritic cells (DCs) cause weak responses and hamper the subsequent T cell responses. Here, we report on an alum-stabilized Pickering emulsion (APE) that can load a high number of antigens and continue to release them for extensive maturation and activations of antigen-presenting cells (APCs). After two vaccinations, APE/OVA induced both IFN-γ-secreting T cells (Th1) and IL-4-secreting T cells (Th2), generating effector CD8⁺ T cells against tumor growth. Additionally, although they boosted the cellular immune responses in the spleen, we found t

SUBMITTER: Peng S 

PROVIDER: S-EPMC10383433 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature