SARS-CoV-2 Recombinants: Genomic Comparison between XBF and Its Parental Lineages.

ABSTRACT: Recombination events are very common and represent one of the primary drivers of RNA virus evolution. The XBF SARS-CoV-2 lineage is one of the most recently generated recombinants during the COVID-19 pandemic. It is a recombinant of BA.5.2.3 and BA.2.75.3, both descendants of lineages that caused many concerns (BA.5 and BA.2.75, respectively). Here, we performed a genomic survey focused on comparing the recombinant XBF with its parental lineages to provide a comprehensive assessment of the evolutionary potential, epidemiological trajectory, and potential risks. Genetic analyses indicated that although XBF initially showed the typical expansion depicted by a steep curve, causing several concerns, currently there is no indication of significant expansion potential or a contagion rate surpass

SUBMITTER: Scarpa F 

PROVIDER: S-EPMC10383834 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature