Phenylalanine and Tryptophan-Based Surfactants as New Antibacterial Agents: Characterization, Self-Aggregation Properties, and DPPC/Surfactants Vesicles Formulation.

ABSTRACT: Cationic surfactants based on phenylalanine (C_nPC₃NH₃Cl) and tryptophan (C_nTC₃NH₃Cl) were synthesized using renewable raw materials as starting compounds and a green synthetic procedure. The synthesis, acid-base equilibrium, aggregation properties, and antibacterial activity were investigated. Conductivity and fluorescence were used to establish critical micelle concentrations. Micellization of C_nPC₃NH₃Cl and C_nTC₃NH₃Cl occurred in the ranges of 0.42-16.2 mM and 0.29-4.6 mM, respectively. Since those surfactants have some acidic character, the apparent pK_a was determined through titrations, observing increasing acidity with increasing chain length a

SUBMITTER: Hafidi Z 

PROVIDER: S-EPMC10384047 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature