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Targeting Potential of Innate Lymphoid Cells in Melanoma and Other Cancers.

ABSTRACT: Reinvigorating the killing function of tumor-infiltrating immune cells through the targeting of regulatory molecules expressed on lymphocytes has markedly improved the prognosis of cancer patients, particularly in melanoma. While initially thought to solely strengthen adaptive T lymphocyte anti-tumor activity, recent investigations suggest that other immune cell subsets, particularly tissue-resident innate lymphoid cells (ILCs), may benefit from immunotherapy treatment. Here, we describe the recent findings showing immune checkpoint expression on tissue-resident and tumor-infiltrating ILCs and how their effector function is modulated by checkpoint blockade-based therapies in cancer. We discuss the therapeutic potential of ILCs beyond the classical PD-1 and CTLA-4 regulatory molecules, exploring other possibilities to manipulate ILC effector function to further impede tumor growth and quench disease progression.

SUBMITTER: Seo H

PROVIDER: S-EPMC10384206 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Targeting Potential of Innate Lymphoid Cells in Melanoma and Other Cancers.

Seo Hobin H Verma Amisha A Kinzel Megan M Huang Qiutong Q Mahoney Douglas J DJ Jacquelot Nicolas N

Pharmaceutics 20230721 7

Reinvigorating the killing function of tumor-infiltrating immune cells through the targeting of regulatory molecules expressed on lymphocytes has markedly improved the prognosis of cancer patients, particularly in melanoma. While initially thought to solely strengthen adaptive T lymphocyte anti-tumor activity, recent investigations suggest that other immune cell subsets, particularly tissue-resident innate lymphoid cells (ILCs), may benefit from immunotherapy treatment. Here, we describe the rec ...[more]

PMID: 37514187

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