MGWAS-Explorer 2.0: Causal Analysis and Interpretation of Metabolite-Phenotype Associations.

ABSTRACT: Metabolomics-based genome-wide association studies (mGWAS) are key to understanding the genetic regulations of metabolites in complex phenotypes. We previously developed mGWAS-Explorer 1.0 to link single-nucleotide polymorphisms (SNPs), metabolites, genes and phenotypes for hypothesis generation. It has become clear that identifying potential causal relationships between metabolites and phenotypes, as well as providing deep functional insights, are crucial for further downstream applications. Here, we introduce mGWAS-Explorer 2.0 to support the causal analysis between >4000 metabolites and various phenotypes. The results can be interpreted within the context of semantic triples and molecular quantitative trait loci (QTL) data. The underlying R package is released for reproducible analysis.

SUBMITTER: Chang L 

PROVIDER: S-EPMC10384390 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature