Generation and Efficacy of Two Chimeric Viruses Derived from GPE^- Vaccine Strain as Classical Swine Fever Vaccine Candidates.

ABSTRACT: A previous study proved that vGPE^- mainly maintains the properties of classical swine fever (CSF) virus, which is comparable to the GPE^- vaccine seed and is a potentially valuable backbone for developing a CSF marker vaccine. Chimeric viruses were constructed based on an infectious cDNA clone derived from the live attenuated GPE^- vaccine strain as novel CSF vaccine candidates that potentially meet the concept of differentiating infected from vaccinated animals (DIVA) by substituting the glycoprotein E^rns of the GPE^- vaccine strain with the corresponding region of non-CSF pestiviruses, either pronghorn antelope pestivirus (PAPeV) or Phocoena pestivirus (PhoPeV). High viral growth and genetic stability after serial passages of the chimer

SUBMITTER: Huynh LT 

PROVIDER: S-EPMC10384557 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature