Kinetics of Abnormal Prion Protein in Blood of Transgenic Mice Experimentally Infected by Multiple Routes with the Agent of Variant Creutzfeldt-Jakob Disease.

ABSTRACT: Transmissible spongiform encephalopathies (TSEs) or prion diseases are characterized by the accumulation in affected tissues of the abnormal prion protein PrP^TSE. We previously demonstrated PrP^TSE in the blood of macaques experimentally infected with variant Creutzfeldt-Jakob disease (vCJD), a human TSE, months to years prior to clinical onset. That work supported the prospect of using PrP^TSE as a blood biomarker to detect vCJD and possibly other human TSEs before the onset of overt illness. However, our results also raised questions about the origin of PrP^TSE detected in blood early after inoculation and the effects of dose and route on the timing of the appearance of PrP^TSE. To investigate these questions, we inoculated vCJD-suscepti

SUBMITTER: Yakovleva O 

PROVIDER: S-EPMC10384726 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature