Prenatal Cadmium Exposure and Maternal Sex Steroid Hormone Concentrations across Pregnancy.

ABSTRACT: Cadmium exposure has been associated with adverse perinatal outcomes. One possible mechanism is endocrine disruption. Studies of non-pregnant adults suggest that cadmium impacts androgen production; here, we examined these associations during pregnancy. Participants in the Understanding Pregnancy Signals and Infant Development (UPSIDE) cohort provided biospecimens and questionnaire data in each trimester (n = 272). We quantified urinary cadmium, serum total testosterone (TT), estrone, estradiol, and estriol and serum free testosterone (fT). In adjusted longitudinal models, we examined sex steroid concentrations across pregnancy in relation to specific gravity-adjusted, ln-transformed cadmium concentrations. Additionally, we examined trimester-specific associations and stratified models by

SUBMITTER: Rivera-Nunez Z 

PROVIDER: S-EPMC10384739 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature