Virus-Based Biological Systems as Next-Generation Carriers for the Therapy of Central Nervous System Diseases.

ABSTRACT: Central nervous system (CNS) diseases are currently a major challenge in medicine. One reason is the presence of the blood-brain barrier, which is a significant limitation for currently used medicinal substances that are characterized by a high molecular weight and a short half-life. Despite the application of nanotechnology, there is still the problem of targeting and the occurrence of systemic toxicity. Viral vectors and virus-like particles (VLPs) may provide a promising solution to these challenges. Their small size, biocompatibility, ability to carry medicinal substances, and specific targeting of neural cells make them useful in research when formulating a new generation of biological carriers. Additionally, the possibility of genetic modification has the potential for gene therapy.

SUBMITTER: Nowak I 

PROVIDER: S-EPMC10384784 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature