Multi-View Learning to Unravel the Different Levels Underlying Hepatitis B Vaccine Response.

ABSTRACT: The immune system acts as an intricate apparatus that is dedicated to mounting a defense and ensures host survival from microbial threats. To engage this faceted immune response and provide protection against infectious diseases, vaccinations are a critical tool to be developed. However, vaccine responses are governed by levels that, when interrogated, separately only explain a fraction of the immune reaction. To address this knowledge gap, we conducted a feasibility study to determine if multi-view modeling could aid in gaining actionable insights on response markers shared across populations, capture the immune system's diversity, and disentangle confounders. We thus sought to assess this multi-view modeling capacity on the responsiveness to the Hepatitis B virus (HBV) vaccination. Seroc

SUBMITTER: Affaticati F 

PROVIDER: S-EPMC10384938 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature