Ontology highlight
ABSTRACT:
SUBMITTER: Vuu YM
PROVIDER: S-EPMC10385015 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Vuu Yen My YM Kadar Shahib Ashraf A Rastegar Mojgan M
Pharmaceuticals (Basel, Switzerland) 20230622 7
Statins are common drugs that are clinically used to reduce elevated plasma cholesterol levels. Based on their solubility, statins are considered to be either hydrophilic or lipophilic. Amongst them, simvastatin has the highest lipophilicity to facilitate its ability to cross the blood-brain barrier. Recent studies have suggested that simvastatin could be a promising therapeutic option for different brain complications and diseases ranging from brain tumors (i.e., medulloblastoma and glioblastom ...[more]