System Biology Approach to Identify the Hub Genes and Pathways Associated with Human H5N1 Infection.

ABSTRACT:

Introduction

H5N1 is a highly pathogenic avian influenza virus that can infect humans and has an estimated fatality rate of 53%. As shown by the current situation of the COVID-19 pandemic, emerging and re-emerging viruses such as H5N1 have the potential to cause another pandemic. Thus, this study outlined the hub genes and pathways associated with H5N1 infection in humans.

Methods

The genes associated with H5N1 infection in humans were retrieved from the NCBI Gene database using "H5N1 virus infection" as the keyword. The genes obtained were investigated for protein-protein interaction (PPI) using STRING version 11.5 and studied for functional enrichment analysis using DAVID 2021. Further, the PPI network was visualised and analysed using Cytoscape 3.7.2, and the hub genes we

SUBMITTER: Chaudhary RK 

PROVIDER: S-EPMC10385284 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature