Covalent Inhibitors for Neglected Diseases: An Exploration of Novel Therapeutic Options.

ABSTRACT: Neglected diseases, primarily found in tropical regions of the world, present a significant challenge for impoverished populations. Currently, there are 20 diseases considered neglected, which greatly impact the health of affected populations and result in difficult-to-control social and economic consequences. Unfortunately, for the majority of these diseases, there are few or no drugs available for patient treatment, and the few drugs that do exist often lack adequate safety and efficacy. As a result, there is a pressing need to discover and design new drugs to address these neglected diseases. This requires the identification of different targets and interactions to be studied. In recent years, there has been a growing focus on studying enzyme covalent inhibitors as a potential treatment

SUBMITTER: Alves ETM 

PROVIDER: S-EPMC10385647 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature