Dietary Supplementation of Aspirin Promotes Drosophila Defense against Viral Infection.

ABSTRACT: Aspirin, also known as acetylsalicylic acid, is widely consumed as a pain reliever and an anti-inflammatory as well as anti-platelet agent. Recently, our studies using the animal model of Drosophila demonstrated that the dietary supplementation of aspirin renovates age-onset intestinal dysfunction and delays organismal aging. Nevertheless, it remains probable that aspirin plays functional roles in other biological activities, for instance antiviral defense reactions. Intriguingly, we observed that the replications of several types of viruses were drastically antagonized in Drosophila macrophage-like S2 cells with the addition of aspirin. Further in vivo experimental approaches illustrate that adult flies consuming aspirin harbor higher resistances to viral infections with res

SUBMITTER: Kong F 

PROVIDER: S-EPMC10385701 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature