Novel Metallo-β-Lactamase bla_CVI-1 Isolated from a Chromobaterium violaceum Clinical Strain Resistant to Colistin.

ABSTRACT:

Objective

We aimed to describe a colistin (COL)-resistant (R) Chromobacterium violaceum (Cvi) isolate from a septic patient in Argentina expressing a previously unknown gene, bla_CVI-1.

Methods

In 2019, a 12 year old child was injured with a thorn in a lagoon. The child was hospitalized due to sepsis and multiple abscesses. Cvi was isolated from skin and soft tissue and tracheal aspirate. The patient was successfully treated with imipenem (IMI) plus amikacin. Antimicrobial susceptibility was assessed by disk diffusion, broth microdilution, and the E-test. Carbapenemase activity was assayed by double-disk synergy and microbiological tests. Resistance, virulence, and additional gene searches were performed by in silico analysis of sequences obtained by

SUBMITTER: Gomez SA 

PROVIDER: S-EPMC10385785 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature