Panapophenanthrin, a Rare Oligocyclic Diterpene from Panus strigellus.

ABSTRACT: During the course of our search for biologically active secondary metabolites from fungal cultures, a new oligocyclic diterpenoidal derivative, panapophenanthrin (1), was isolated from Panus strigellus. In addition, two known metabolites, panepophenanthrin (2) and dihydrohypnophilin (3), were also obtained. The chemical structures of the isolated compounds were elucidated based on extensive 1D and 2D NMR spectral analyses together with high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). The absolute configuration was determined through TDDFT-ECD calculations. All of the compounds were assessed for their antimicrobial and cytotoxic activities. Compounds 1 and 3 showed moderate to weak activities in the performed antimicrobial assa

SUBMITTER: Llanos-Lopez NA 

PROVIDER: S-EPMC10385786 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature