Proteomic analysis identifies subgroups of patients with active systemic lupus erythematosus.

ABSTRACT:

Objective

Systemic lupus erythematosus (SLE) is a clinically and biologically heterogenous autoimmune disease. We aimed to investigate the plasma proteome of patients with active SLE to identify novel subgroups, or endotypes, of patients.

Method

Plasma was collected from patients with active SLE who were enrolled in the British Isles Lupus Assessment Group Biologics Registry (BILAG-BR). The plasma proteome was analysed using a data-independent acquisition method, Sequential Window Acquisition of All theoretical mass spectra mass spectrometry (SWATH-MS). Unsupervised, data-driven clustering algorithms were used to delineate groups of patients with a shared proteomic profile.

Results

In 223 patients, six clusters were identified based on quantification of 581 proteins.

SUBMITTER: Su KYC 

PROVIDER: S-EPMC10385905 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature