Sertaconazole-repurposed nanoplatform enhances lung cancer therapy via CD44-targeted drug delivery.

ABSTRACT:

Background

Lung cancer is one of the most frequent causes of cancer-related deaths worldwide. Drug repurposing and nano-drug delivery systems are attracting considerable attention for improving anti-cancer therapy. Sertaconazole (STZ), an antifungal agent, has been reported to exhibit cytotoxicity against both normal and tumor cells, and its medical use is limited by its poor solubility. In order to overcome such shortcomings, we prepared a drug-repurposed nanoplatform to enhance the anti-tumor efficiency.

Methods

Nanoplatform was prepared by thin film dispersion. Drug release studies and uptake studies were measured in vitro. Subsequently, we verified the tumor inhibition mechanisms of HTS NPs through apoptosis assay, immunoblotting and reactive oxygen species (ROS) detecti

SUBMITTER: Liu R 

PROVIDER: S-EPMC10385912 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature