Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies.

ABSTRACT: Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune responses. Their function and expression in the tumor microenvironment make them attractive targets for immunotherapy, leading to the development of IL-2/IL-2R-targeted therapeutic strategies. However, the dynamic interplay between IL-2/IL-2R and various immune cells and their dual roles in promoting immune activation and tolerance presents a complex landscape for clinical exploitation. This review discusses the pivotal roles of IL-2 and IL-2R in tumorigenesis, shedding light on their potential as diagnostic and prognostic markers and their therapeutic manipulation in cancer. It underlines the necessity to balance the anti-tumor activity with regulatory T-cell expansion and evaluates strategies such as dose

SUBMITTER: Muhammad S 

PROVIDER: S-EPMC10385932 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature