Ontology highlight
ABSTRACT:
SUBMITTER: Berckmans Y
PROVIDER: S-EPMC10385967 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Berckmans Yani Y Hoffert Yannick Y Vankerckhoven Ann A Dreesen Erwin E Coosemans An A
Pharmaceutics 20230622 7
The lethality of patients with ovarian cancer (OC) remains high. Current treatment strategies often do not lead to the desired outcome due to the development of therapy resistance, resulting in high relapse rates. Additionally, clinical trials testing immunotherapy against OC have failed to reach significant results to date. The OC tumor microenvironment and specifically myeloid-derived suppressor cells (MDSC) are known to generate immunosuppression and inhibit the anti-tumor immune response fol ...[more]