Resistome expansion in disease-associated human gut microbiomes.

ABSTRACT:

Background

The resistome, the collection of antibiotic resistance genes (ARGs) in a microbiome, is increasingly recognised as relevant to the development of clinically relevant antibiotic resistance. Many metagenomic studies have reported resistome differences between groups, often in connection with disease and/or antibiotic treatment. However, the consistency of resistome associations with antibiotic- and non-antibiotic-treated diseases has not been established. In this study, we re-analysed human gut microbiome data from 26 case-control studies to assess the link between disease and the resistome.

Results

The human gut resistome is highly variable between individuals both within and between studies, but may also vary significantly between case and control groups even in t

SUBMITTER: Fredriksen S 

PROVIDER: S-EPMC10386251 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature