A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer.

ABSTRACT:

Background

Prostate cancer is a major cause of cancer morbidity and mortality in men worldwide. Androgen deprivation therapy (ADT) has proven effective in early-stage androgen-sensitive disease, but prostate cancer gradually develops into an androgen-resistant metastatic state in the vast majority of patients. According to our oncogene-induced model for cancer development, senescence is a major tumor progression barrier. However, whether senescence is implicated in the progression of early-stage androgen-sensitive to highly aggressive castration-resistant prostate cancer (CRPC) remains poorly addressed.

Methods

Androgen-dependent (LNCaP) and -independent (C4-2B and PC-3) cells were treated or not with enzalutamide, an Androgen Receptor (AR) inhibitor. RNA sequencing and path

SUBMITTER: Mourkioti I 

PROVIDER: S-EPMC10386253 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature