Identification of Immunodominant Proteins of the <i>Leishmania (Viannia) naiffi</i> SubProteome as Pan-Specific Vaccine Targets against Leishmaniasis.

ABSTRACT: Leishmaniasis is a wide-spectrum disease caused by parasites from Leishmania genus. A well-modulated immune response that is established after the long-lasting clinical cure of leishmaniasis can represent a standard requirement for a vaccine. Previous studies demonstrated that Leishmania (Viannia) naiffi causes benign disease and its antigens induce well-modulated immune responses in vitro. In this work we aimed to identify the immunodominant proteins present in the soluble extract of L. naiffi (sLnAg) as candidates for composing a pan-specific anti-leishmaniasis vaccine. After immunoblotting using cured patients of cutaneous leishmaniasis sera and proteomics approaches, we identified a group of antigenic proteins from the sLnAg. In silico analyses allowed us to

SUBMITTER: Jesus-Oliveira P 

PROVIDER: S-EPMC10386316 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature