PH-Responsive Cobalt(II)-Coordinated Assembly Containing Quercetin for Antimicrobial Applications.

ABSTRACT: The development of novel drug delivery systems (DDSs) with promising antibacterial properties is essential for facing the emergency of increasing resistance to antimicrobial agents. The antibacterial features of quercetin and its metal complexes have been broadly investigated. However, several drawbacks affect their activity and effectiveness. In this work, we propose a DDS based on a pH-responsive cobalt(II)-coordinated assembly containing quercetin and polyacrylic acid. This system is suggested to trigger the release of the model drug in a pH-dependent mode by exploiting the localized acidic environment at the bacterial infection sites under anaerobic conditions. The delivery system has been designed by accurately examining the species and the multiple equilibria occurring in solution am

SUBMITTER: Santonoceta GDG 

PROVIDER: S-EPMC10386366 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature