Self-Aggregation, Antimicrobial Activity and Cytotoxicity of Ester-Bonded Gemini Quaternary Ammonium Salts: The Role of the Spacer.

ABSTRACT: Five ester-bonded gemini quaternary ammonium surfactants C₁₂-E_n-C₁₂ (n = 2, 4, 6), with a flexible spacer group, and C₁₂-B_m-C₁₂ (m = 1, 2), with rigid benzene spacers, were synthesized via a two-step reaction and analyzed. Furthermore, the effects of the spacer structure, spacer length and polymerization degree on the self-aggregation, antimicrobial activity and cytotoxicity of C₁₂-E_n-C₁₂ and C₁₂-B_m-C₁₂ and their corresponding monomer N-dodecyl-N,N,N-trimethyl ammonium chloride DTAC were investigated. The results showed that C₁₂-E_n-C₁₂ and C₁₂-B_m-C₁₂ had markedly lowe

SUBMITTER: Liang Y 

PROVIDER: S-EPMC10386392 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature