A Flexible Kenics Mixer for Applications in Liquid Chromatography.

ABSTRACT: Miniaturization of liquid chromatography could help enhance sensitivity, reduce solvent usage, and detect small quantities of peptides. However, it demands better sample homogenization of the mobile phase. We here developed a mixer design based on the inline Kenics geometry, consisting of a periodic arrangement of twisted blades placed inside a cylindrical capillary that repeatedly cut and stack fluid elements to achieve rapid mixing in laminar flow regimes. The mixer design was optimized with respect to the twist angle and aspect ratio of the mixing units to achieve complete mixing at minimum pressure load cost. Results suggest that for optimal designs, for a mixer volume of ~70 μL, complete mixing is achieved within a distance smaller than 4 cm for a broad set of flow rate conditions ran

SUBMITTER: Dsk P 

PROVIDER: S-EPMC10386428 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature