Pistacia vera Extract Potentiates the Effect of Melatonin on Human Melatonin MT₁ and MT₂ Receptors with Functional Selectivity.

ABSTRACT: Melatonin is a tryptophan derivative synthesized in plants and animals. In humans, melatonin acts on melatonin MT₁ and MT₂ receptors belonging to the G protein-coupled receptor (GPCR) family. Synthetic melatonin receptor agonists are prescribed for insomnia and depressive and circadian-related disorders. Here, we tested 25 commercial plant extracts, reported to have beneficial properties in sleep disorders and anxiety, using cellular assays (2─[¹²⁵I]iodomelatonin binding, cAMP inhibition, ERK1/2 activation and β-arrestin2 recruitment) in mock-transfected and HEK293 cells expressing MT₁ or MT₂. Various melatonin receptor-dependent and -independent effects were observed. Extract 18 (Ex18) from Pistacia vera dried fruits sto

SUBMITTER: Labani N 

PROVIDER: S-EPMC10386454 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature