Identifying circRNA-associated-ceRNA networks in juvenile spondyloarthropathies patients.

ABSTRACT:

Background

Juvenile spondyloarthropathies (JSpA) are defined as a heterogeneous group of diseases that start before the age of 16. The study aimed to identify key genes and pathways that are influenced by circRNAs and to screen potential therapeutic agents for JSpA. The study involved the analysis of circRNA expression profiles, identification of circRNA-miRNA-mRNA regulatory networks, and functional annotation of differentially expressed genes. The results of the study may have provided insights into the molecular mechanisms underlying JSpA and potential therapeutic targets for this disease.

Methods

In this study, sequencing data of circRNA, miRNA, and mRNA were obtained from the GEO datasets. The data were then analyzed to identify candidates for constructing a circRNA-miR

SUBMITTER: Qijiao W 

PROVIDER: S-EPMC10386608 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature